NexGard Combo Spot-on Solution for Cats 0.8-2.5kgEsafoxolaner, eprinomectin & praziquantel

A monthly spot-on for cats built around three actives working together: esafoxolaner for fleas and ticks, eprinomectin for heartworm prevention and two of the common intestinal roundworms/hookworms, and praziquantel for tapeworm. Applied to the skin at the back of the neck rather than given orally, it's absorbed through the skin into the bloodstream over the following hours. Sold as two colour-coded applicators — purple for small cats, yellow for large cats — same solution, different volume per dose.

Registered for flea and tick treatment, heartworm prevention, and treatment of roundworm, hookworm and tapeworm.

• Flea Control
• Tick Control
• Monthly Dosing
• Heartworm Prevention
• Worm Control

Ingredients

Active ingredients (fixed concentration, both applicators): Esafoxolaner 12 mg/mL, eprinomectin 4 mg/mL, praziquantel 83 mg/mL. Dose scales with applicator volume.

Looking after it

Part the fur at the back of the neck, between the shoulder blades, and apply the full applicator directly to the skin rather than onto the fur — it needs skin contact to absorb properly. Keep cats separated from each other for a few hours after application so they can't groom the product off one another, and hold off bathing for at least 24 hours either side of a dose if possible. A little hypersalivation right after application is common if the cat licks the spot before it's dried down and isn't usually a sign anything's wrong. Same day each month keeps both the flea/tick and the heartworm-prevention sides working properly — heartworm prevention in particular relies on regular timing rather than "close enough." Wash your own hands after applying, and avoid touching the application site yourself until it's dry. Double-check the applicator colour against the cat's current weight at every purchase, the same way you'd re-check a dog's weight band — a cat that's grown out of the purple pack needs to move up to yellow. Collie, Australian Shepherd and other herding breeds: stick to the labelled dose for the weight band — don't be tempted to round up "to be safe," since milbemycin oxime is the drug class linked to sensitivity in dogs carrying the MDR1 mutation common in these breeds. If a heartworm test hasn't been done recently in an area where heartworm is present, ask the vet about testing before starting, since giving a preventive to an already-infected dog isn't the same as using it preventively.